Article

Bleomycin induces active-centromere damage and cytoplasmic mislocalization of centromeric chromatin in fibroblasts

2025-08-27

Abstract excerpt

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which genomic sources of instability and their immunological consequences remain poorly defined. We show that bleomycin, a widely used SSc fibrosis model, induces DNA double-strand breaks (DSBs) at active centromeres. Similar centromeric damage signatures were observed in fibroblasts from patients with limited cutaneous SSc, consistent with prior observa...

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Identifiers and source

Literature Corpus work: d44d9949-81f3-50d0-ac09-71b1616a0def
DOI: 10.1101/2025.08.22.671795

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