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Article

DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage.

Cell death & disease - 11 Jun 2022

Shih Hsueh-Tzu, Chen Wei-Yi, Wang Hsin-Yen, Chao Tung, Huang Hsien-Da, Chou Chih-Hung, Chang Zee-Fen

Abstract excerpt

This study used DNA methyltransferase 3b (DNMT3b) knockout cells and the functional loss of DNMT3b mutation in immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) cells to understand how DNMT3b dysfunction causes genome instability. We demonstrated that R-loops contribute to DNA damages in DNMT3b knockout and ICF cells. More prominent DNA damage signal in DNMT3b knockout cells was due to the...

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Source

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Identifiers

PMID: 35688824
DOI: 10.1038/s41419-022-04989-1
PMCID: PMC9187704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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