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Article

Association Between DNA Damage Response, Fibrosis and Type I Interferon Signature in Systemic Sclerosis

2 Oct 2020

Abstract excerpt

Increased endogenous DNA damage and type I interferon pathway activation have been implicated in Systemic Sclerosis (SSc) pathogenesis. Since experimental evidence suggests an interplay between DNA damage response/repair (DDR/R) and immune response, we hypothesized that deregulated DDR/R is associated with type I interferon signature and/or fibrosis extent in SSc. DNA damage levels, oxidative stress, induction of...

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PMID: 33123169
DOI: 10.3389/fimmu.2020.582401

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