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Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis

27 Jan 2022

Abstract excerpt

BACKGROUND: To investigate the role of cell senescence in systemic sclerosis (SSc), we analyzed telomere shortening (TS) in SSc patients and the effect of targeting DNA damage in the bleomycin model of skin fibrosis. RESULTS: Telomere length (TL) in blood leukocytes of 174 SSc patients and 68 healthy controls was measured by Southern blot, and we found shorter age-standardized TL in SSc patients compared to...

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PMID: 35086525
DOI: 10.1186/s12979-022-00263-2

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