Article

A PERK-FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

2026-02-18

Abstract excerpt

<h4>Objective</h4> Diffuse cutaneous systemic sclerosis (dcSSc) is a life-limiting fibrotic disease. We and others have shown that dcSSc fibroblasts accumulate numerous somatic mutations associated with senescence-like features; however, the mechanism(s) enabling their survival remain unclear. <h4>Methods</h4> Skin biopsies were obtained from lesional tissues from dcSSc (n=10), dcSSc treated with autologous hema...

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Literature Corpus work: 2cdee68c-5652-5a4f-bf03-f617d319983f
DOI: 10.64898/2026.02.17.706443

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