Article

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

2024-04-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Exposure of systemic lupus erythematosus (SLE) patients to ultraviolet light B (UVB) triggers local and systemic inflammation, with cytosolic DNA sensing and induction of type I interferons (IFNs) known to play a role. We previously identified TRIM21 as a negative regulator of DNA sensing and IFN expression. Here we explore the role of TRIM21 in regulating local and systemi...

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Literature Corpus work: 5e531637-f2d3-5bb4-acc3-aacf929d6b24
DOI: 10.1101/2024.04.10.588897

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