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Article

Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis.

Nature communications - 15 Oct 2024

Vijayraghavan Sriram, Blouin Thomas, McCollum James, Porcher Latarsha, Virard François, Zavadil Jiri, Feghali-Bostwick Carol, Saini Natalie

Abstract excerpt

Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens prognosis. However, the mechanisms underlying systemic sclerosis initiation, propagation, and cancer development are poorly understood. We hypothesize that the...

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Identifiers

PMID: 39406724
DOI: 10.1038/s41467-024-53332-z
PMCID: PMC11480385

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