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Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

18 Nov 2022

Abstract excerpt

Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite the fact that many centromere proteins were discovered in patients with SSc. Here we report that lesion skin fibroblasts from SSc patients show marked alterations in centromeric DNA. SSc fibroblasts also show DNA damage, abnormal chromosome segregation, aneuploidy (only in diffuse cutaneous (dcSSc)) and micronuclei (in all types of...

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PMID: 36400785
DOI: 10.1038/s41467-022-34775-8

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