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Article

Nucleosome scaffolding by Brd4 tandem bromodomains in acetylation-dependent chromatin compartmentalization

2019-07-11

Abstract excerpt

Bromodomain binding of acetyl-lysine residues is a crucial step in many epigenetic mechanisms governing transcription. Nearly half of human bromodomains exist in tandem with at least one other bromodomain on a single protein. The Bromodomain and ExtraTerminal domain (BET) familyof proteins (BrdT, Brd2, Brd3 and Brd4) each encode two bromodomains at their N -termini and are important regulators of acetylation-depe...

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Literature Corpus work
4d8e182a-a245-5aa1-9548-250beca8cae9
DOI
10.1101/699967
Open publication

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Nucleosome scaffolding by Brd4 tandem bromodomains in acetylation-dependent chromatin compartmentalizationDOI 10.1101/699967
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