Article

Highly efficient <i>Runx1</i> enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

2021-11-25

Abstract excerpt

<h4>Summary</h4> A cis -regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducible CreER T2 transgenic (Tg) mouse employing previously identified hematopoietic stem cell (HSC) enhancer for Runx1 , eR1 (+24m). Kinetic analysis...

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Literature Corpus work: d40d69e1-1412-5618-87af-dab3c309d6f7
DOI: 10.1101/2021.11.24.469958

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