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Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice

11 Jun 2024

Abstract excerpt

Image-based lineage tracing enables tissue turnover kinetics and lineage potentials of different adult cell populations to be investigated. Previously, we reported a genetic mouse model system, Red2Onco, which ectopically expressed mutated oncogenes together with red fluorescent proteins (RFP). This system enabled the expansion kinetics and neighboring effects of oncogenic clones to be dissected. We now report...

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PMID: 38862535
DOI: 10.1038/s41467-024-49382-y

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