Article
TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells.
Nature communications - 1 Jan 2013
Schneider Ralph P, Garrobo Ianire, Foronda Miguel, Palacios Jose A, Marión Rosa M, Flores Ignacio, Ortega Sagrario, Blasco Maria A
Abstract excerpt
TRF1 is a component of the shelterin complex that protects chromosome ends. TRF1 deficiency leads to early embryonic lethality and to severe organ atrophy when deleted in adult tissues. Here we generate a reporter mouse carrying a knock-in eGFP-TRF1 fusion allele to study the role of TRF1 in stem cell biology and tissue homeostasis. We find that eGFP-TRF1 expression in mice is maximal in known adult stem cell...
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