Article

EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma

2025-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (ES) is an aggressive bone and soft tissue neoplasm characterized by EWSR1/ETS rearrangements and whose cellular origin remains unclear. EWS-FLI1 expression in human pediatric mesenchymal stem cells (hpMSCs) induces a quantitatively and qualitatively different transcriptional response than its expression in human adult MSCs (haMSCs), but fails to form tumors in vivo . ES cells ha...

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Literature Corpus work: 26416c6d-8f2f-5f63-8a09-abb6481c57b2
DOI: 10.1101/2025.01.13.632712

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