Article

A novel <i>kit</i> mutant rat enables hematopoietic stem cell engraftment without irradiation

2023-09-13

Abstract excerpt

<h4>Summary</h4> Hematopoietic stem cell (HSC) transplantation is extensively studied in mouse models, but their limited scale presents challenges for effective engraftment and comprehensive evaluations. Rats, due to their larger size and anatomical similarity to humans, offer a promising alternative. In this study, we establish a rat model with the Kit V834M mutation, mirroring Kit W41 mice often used in KIT s...

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Literature Corpus work: 60eeaff9-55d2-5841-8843-2f22b83ee927
DOI: 10.1101/2023.09.12.556153

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