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T cell development from expanded hematopoietic progenitors reveals progression control by <i>Lmo2</i> , <i>Erg</i> , <i>Spi1</i> , <i>Hoxa9</i> , and <i>Meis1</i>

2025-04-26

Abstract excerpt

To gain access to the earliest stages of T cell development, we adapted a serum-free culture system that expands hematopoietic stem and progenitor-like cells. These expanded cells efficiently undergo normal T-cell differentiation in vivo and in vitro , verified by early gene expression trajectories from single-cell RNA sequencing, though their absolute differentiation speed is slower than that of fresh progenito...

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Literature Corpus work
809a1444-2920-5998-902a-7fff752000b7
DOI
10.1101/2025.04.22.649893
Open publication

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T cell development from expanded hematopoietic progenitors reveals progression control by <i>Lmo2</i> , <i>Erg</i> , <i>Spi1</i> , <i>Hoxa9</i> , and <i>Meis1</i>DOI 10.1101/2025.04.22.649893
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