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Article

A <i>Runx1</i> Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells

30 Aug 2010

Abstract excerpt

Runx1 is essential for the generation of hematopoietic stem cells (HSCs) and is frequently mutated in human leukemias. However, the cis-regulatory mechanisms modulating the Runx1 gene expression remain to be elucidated. Herewith, we report the identification of an intronic Runx1 enhancer, Runx1 +24 mouse conserved noncoding element (mCNE), using a combinatorial in silico approach involving comparative genomics...

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PMID: 20799333
DOI: 10.1002/stem.507

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