Article

Isolation of Pure Disease Specific Aging Trajectories in Spatial Transcriptomics via the Delta–Delta Method

2025-10-03

Abstract excerpt

Disentangling normal aging from disease driven transcriptional change remains a major obstacle for spatial genomics. We introduce the Delta–Delta (ΔΔ) Method, a contrastive trajectory framework that resolves a four-dimensional progression (genes × cell types × brain regions × time) by subtracting the wild type (WT) aging trajectory from the transgenic (TG) trajectory to yield a pure disease trajectory (ΔΔlog₂FC)....

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Literature Corpus work: d3c1cbb3-0ea6-5270-82d4-ae92b869dd83
DOI: 10.1101/2025.10.01.679749

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