Article

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci

2022-09-18

Abstract excerpt

<h4>Summary</h4> Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA-seq of the mouse brain, profiling 1,076 samples from 15 regions across 7 ages and 2 rejuvenation interventions. Our analysis identified a brain-wide gene signature of aging in glial cells, which exhibited spatially defined changes in...

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Literature Corpus work: db6e64c3-379d-5336-8df3-79c9498cc06c
DOI: 10.1101/2022.09.18.508419

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