Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenation

Abstract excerpt

Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk 1 . Brain aging is complex and accompanied by many cellular changes 2–20 . However, the influence that aged cells have on neighboring cells and how this contributes to tissue decline is unknown. More generally, the tools to systematically address this question in aging tissues have not yet been developed....

Topics

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• Aging
• Gene Expression Profiling
• Mice
• Models, Biological
• Phenotype
• Transcriptome

Identifiers and source

Literature Corpus work

2b6097f9-0860-5dad-b166-82bb1cc7b19c

DOI

10.1101/2024.07.16.603809