Article

Neuropathology-based GWAS for Alzheimer’s disease reveals novel susceptibility loci and highlights sex-specific pathways

2023-12-18

Abstract excerpt

Dementia refers to an umbrella phenotype of many different underlying pathologies with Alzheimer’s disease (AD) being the most common type. While Genome-wide Association Studies (GWAS) of clinically defined AD have identified multiple AD susceptibility variants, a significant portion of the heritability remains unexplained highlighting the phenotypic and genetic heterogeneity of the clinically defined entity. Furt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d3b1775c-035c-5db9-a58b-5d432a004ca4
DOI: 10.1101/2023.12.17.23300106

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuropathology-based GWAS for Alzheimer’s disease reveals novel susceptibility loci and highlights sex-specific pathwaysDOI 10.1101/2023.12.17.23300106Read

Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle.Semantic proximity Read

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex-disparitiesSemantic proximity Read

Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomesSemantic proximity Read

Shared Risk Genes and Casual Relationships across Sex Hormone Related Traits and Alzheimer’s DiseaseSemantic proximity Read

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparitiesSemantic proximity Read

Sex specific molecular networks and key drivers of Alzheimer’s diseaseSemantic proximity Read

Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer’s DiseaseSemantic proximity Read

An integrated approach to identifying sex-specific genes, transcription factors, and pathways relevant to Alzheimer’s diseaseSemantic proximity Read

Sex-specific Associations of Gene Expression with Alzheimer’s Disease Neuropathology and Ante-mortem Cognitive PerformanceSemantic proximity Read

Sex-Stratified Transcriptomic Meta-Analysis of Alzheimer’s Disease Reveal Brain Region and Sex Specific DysregulationSemantic proximity Read

An integrated approach to identifying sex-specific genes, transcription factors, and pathways relevant to Alzheimer's diseaseSemantic proximity Read

Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer’s diseaseSemantic proximity Read