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Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes

1 May 2025

Abstract excerpt

INTRODUCTION: Sex differences exist in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. METHODS: We examined brain proteomes profiled from the dorsolateral prefrontal cortex of 770 donors (66.2% female). RESULTS: Proteome-wide differential expression analysis in males and females jointly identified many significant proteins for AD dementia (n = 1228), amyloid beta (n = 1183), tangles (n =...

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PMID: 40346727
DOI: 10.1002/alz.70206

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