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Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

12 Jan 2019

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance remains to be explained. METHODS: We investigated the genetic architecture of AD in four publicly available...

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Alzheimer's disease research and treatments
Genetic Associations and Epidemiology
Renin-Angiotensin System Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30636644
DOI: 10.1186/s13195-018-0458-8

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