Sex-Stratified Transcriptomic Meta-Analysis of Alzheimer’s Disease Reveal Brain Region and Sex Specific Dysregulation

Abstract excerpt

<h4>Objective</h4> Alzheimer disease (AD) is a neurodegenerative disorder leading to cognitive decline. Despite growing recognition of sex differences in epidemiology, symptomatology, and clinical outcomes of AD, the molecular mechanisms underlying these variations remain poorly defined. We performed transcriptome association studies of AD aiming to identify sex-specific and sex-dependent transcriptomic profiles...

Topics

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• Alzheimer Disease
• Apolipoproteins E
• Brain
• Gene Expression Profiling
• Sex Characteristics
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

3994603b-7a2c-51d4-9054-17919f5a8440

DOI

10.1101/2025.06.25.661596