Article
Whole genome sequence analysis of blood lipid levels in >66,000 individuals.
Nature communications - 11 Oct 2022
Selvaraj Margaret Sunitha, Li Xihao, Li Zilin, Pampana Akhil, Zhang David Y, Park Joseph, Aslibekyan Stella, Bis Joshua C, Brody Jennifer A, Cade Brian E, Chuang Lee-Ming, Chung Ren-Hua, Curran Joanne E, de las Fuentes Lisa, de Vries Paul S, Duggirala Ravindranath, Freedman Barry I, Graff Mariaelisa, Guo Xiuqing, Heard-Costa Nancy, Hidalgo Bertha, Hwu Chii-Min, Irvin Marguerite R, Kelly Tanika N, Kral Brian G, Lange Leslie, Li Xiaohui, Lisa Martin, Lubitz Steven A, Manichaikul Ani W, Michael Preuss, Montasser May E, Morrison Alanna C, Naseri Take, O'Connell Jeffrey R, Palmer Nicholette D, Peyser Patricia A, Reupena Muagututia S, Smith Jennifer A, Sun Xiao, Taylor Kent D, Tracy Russell P, Tsai Michael Y, Wang Zhe, Wang Yuxuan, Bao Wei, Wilkins John T, Yanek Lisa R, Zhao Wei, Arnett Donna K, Blangero John, Boerwinkle Eric, Bowden Donald W, Chen Yii-Der Ida, Correa Adolfo, Cupples L Adrienne, Dutcher Susan K, Ellinor Patrick T, Fornage Myriam, Gabriel Stacey, Germer Soren, Gibbs Richard, He Jiang, Kaplan Robert C, Kardia Sharon L R, Kim Ryan, Kooperberg Charles, Loos Ruth J F, Viaud-Martinez Karine A, Mathias Rasika A, McGarvey Stephen T, Mitchell Braxton D, Nickerson Deborah, North Kari E, Psaty Bruce M, Redline Susan, Reiner Alexander P, Vasan Ramachandran S, Rich Stephen S, Willer Cristen, Rotter Jerome I, Rader Daniel J, Lin Xihong, Peloso Gina M, Natarajan Pradeep
Abstract excerpt
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partly due to limited sample sizes, ancestral diversity, and interpretation of clinical significance. Among 66,329 ancestrally diverse (56% non-European) participants,...
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