Article

Detecting hierarchical 3-D genome domain reconfiguration with network modularity

2016-11-22

Abstract excerpt

Mammalian genomes are folded in a hierarchy of topologically associating domains (TADs), subTADs and looping interactions. The nested nature of chromatin domains has rendered it challenging to identify a sensitive and specific metric for detecting subTADs and quantifying their dynamic reconfiguration across cellular states. Here, we apply graph theoretic principles to quantify hierarchical folding patterns in high...

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Literature Corpus work: d3771236-0333-5177-8d3a-d0f77a2df192
DOI: 10.1101/089011

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