Article

Concurrent profiling of multiscale 3D genome organization and gene expression in single mammalian cells

2023-07-25

Abstract excerpt

The organization of mammalian genomes within the nucleus features a complex, multiscale three-dimensional (3D) architecture. The functional significance of these 3D genome features, however, remains largely elusive due to limited single-cell technologies that can concurrently profile genome organization and transcriptional activities. Here, we report GAGE-seq, a highly scalable, robust single-cell co-assay that si...

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Literature Corpus work: 20a4b30b-4dd2-543e-b5aa-82311070322b
DOI: 10.1101/2023.07.20.549578

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