Article

Hotspot DNMT3A mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry response

2021-05-26

Abstract excerpt

<title>Abstract</title> <p>Somatic mutations in DNA Methyltransferase 3A (<italic>DNMT3A</italic>) are among the most frequent alterations in clonal hematopoiesis (CH) and Acute Myeloid Leukemia (AML), with a hotspot in exon 23 at arginine 882 (<italic>DNMT3A</italic>-R882). Here we demonstrate that <italic>DNMT3A-</italic>R882H-dependent CH- and AML cells are specifically susceptible to the hypomethylating agent...

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Literature Corpus work: 774bbd41-9a1d-5cd5-bbac-0a839a7a45db
DOI: 10.21203/rs.3.pex-1436/v1

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