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Article

DNA methyltransferase 1 knockdown activates a replication stress checkpoint.

Molecular and cellular biology - 1 Oct 2006

Unterberger Alexander, Andrews Stephen D, Weaver Ian C G, Szyf Moshe

Abstract excerpt

DNA methyltransferase 1 (DNMT1) is an important component of the epigenetic machinery and is responsible for copying DNA methylation patterns during cell division. Coordination of DNA methylation and DNA replication is critical for maintaining epigenetic programming. Knockdown of DNMT1 leads to inhibition of DNA replication, but the mechanism has been unclear. Here we show that depletion of DNMT1 with either...

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Source

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Identifiers

PMID: 17015478
DOI: 10.1128/MCB.01887-05
PMCID: PMC1636877

Genes

DNMT1
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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