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Article

Combination strategies to promote sensitivity to cytarabine-induced replication stress in acute myeloid leukemia with and without DNMT3A mutations.

Experimental hematology - 1 Jun 2022

Shabashvili Daniil E, Feng Yang, Kaur Prabhjot, Venugopal Kartika, Guryanova Olga A

Abstract excerpt

Cytarabine and other chain-terminating nucleoside analogs that damage replication forks in rapidly proliferating cells are a cornerstone of leukemia chemotherapy, yet the outcomes remain unsatisfactory because of resistance and toxicity. Better understanding of DNA damage repair and downstream effector mechanisms in different disease subtypes can guide combination strategies that sensitize leukemia cells to...

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Identifiers

PMID: 35306047
DOI: 10.1016/j.exphem.2022.03.008
PMCID: PMC9133110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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