Article
The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.
Communications biology - 3 Nov 2022
Bhogal Balpreet, Weir Barbara A, Crescenzo Ramona, Marien Ann, Kwon Min Chul, Philippar Ulrike, Cowley Glenn S
Abstract excerpt
Aberrant DNA methylation patterns are a prominent feature of cancer. Methylation of DNA is mediated by the DNA methyltransferase (DNMT) protein family, which regulates de novo (DNMT3A and DNMT3B) and maintenance (DNMT1) methylation. Mutations in DNMT3A are observed in approximately 22% of acute myeloid leukemia (AML). We hypothesized that DNMT1 or DNMT3B could function as a synthetic lethal therapeutic strategy...
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