DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.

doi:10.1158/1078-0432.CCR-21-2863

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Article

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2022

Venugopal Kartika, Feng Yang, Nowialis Pawel, Xu Huanzhou, Shabashvili Daniil E, Berntsen Cassandra M, Kaur Prabhjot, Krajcik Kathryn I, Taragjini Christina, Zaroogian Zachary, Casellas Román Heidi L, Posada Luisa M, Gunaratne Chamara, Li Jianping, Dupéré-Richer Daphné, Bennett Richard L, Pondugula Santhi, Riva Alberto, Cogle Christopher R, Opavsky Rene, Law Brian K, Bhaduri-McIntosh Sumita, Kubicek Stefan, Staber Philipp B, Licht Jonathan D, Bird Jonathan E, Guryanova Olga A

Abstract excerpt

PURPOSE: In acute myeloid leukemia (AML), recurrent DNA methyltransferase 3A (DNMT3A) mutations are associated with chemoresistance and poor prognosis, especially in advanced-age patients. Gene-expression studies in DNMT3A-mutated cells identified signatures implicated in deregulated DNA damage response and replication fork integrity, suggesting sensitivity to replication stress. Here, we tested whether...

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Identifiers

PMID: 34716195
DOI: 10.1158/1078-0432.CCR-21-2863
PMCID: PMC8866212

Genes

DNMT3A
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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