Back to search

Article

Abi3 regulates microglial ramification and dynamic tissue surveillance <i>in vivo</i>

2021-03-19

Abstract excerpt

A rare coding variant of Abelson-interactor gene family member 3 (Abi3) is associated with increased risk of late-onset Alzheimer’s Disease (AD). Although Abi3 is recognised as a core microglial gene, its role in microglia is largely unknown. Here we demonstrate that Abi3 is crucial for normal microglial morphology, distribution, and homeostatic tissue surveillance activity in vivo .

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d3428625-a263-56c6-9281-f1555bfcabc4
DOI
10.1101/2021.03.19.436147
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Abi3 regulates microglial ramification and dynamic tissue surveillance <i>in vivo</i>DOI 10.1101/2021.03.19.436147
Investigation of the ABI3 protein in microglia and its association with Alzheimer's disease in TgCRND8 mouse modelSemantic proximity
Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosisSemantic proximity
Deletion of <i>Abi3</i> / <i>Gngt2</i> influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity
ABI3 deletion in TgCRND8 mice is associated with reduced amyloid plaque pathology and altered glial responseSemantic proximity
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity
Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brainSemantic proximity
The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer’s disease progressionSemantic proximity
IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s diseaseSemantic proximity
Genetic Validation of ABI3 p.S209F Variant and Its effects On Early Brain Pathology in Asymptomatic Elderly IndividualsSemantic proximity
The <i>APOE</i> isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s diseaseSemantic proximity
Microglial BIN1 deficiency elicits enhanced microglial inflammatory responses that mimic early AD pathologySemantic proximity
Genetic Validation of ABI3 p.Ser209Phe Variant and Its effects On Early Brain Pathology in Asymptomatic Elderly IndividualsSemantic proximity
Select a neighboring publication to make it the new centre.