Article

Deletion of <i>Abi3</i> / <i>Gngt2</i> influences age-progressive amyloid β and tau pathologies in distinctive ways

2021-11-09

Abstract excerpt

The S209F variant of Abelson Interactor Protein 3 ( ABI3 ) increases risk for Alzheimer’s disease (AD), but little is known about ABI3 function. RNAscope showed Abi3 is expressed in microglial and non-microglial cells, though its increased expression appears to be driven in plaque-associated microglia. Here, we evaluated Abi3 - /- mice and document that both Abi3 and its overlapping gene, Gngt2 , are disrupte...

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Literature Corpus work: a6555ee0-5c19-54d8-b3da-823013cf3ce3
DOI: 10.1101/2021.11.08.467701

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