Article

Genetic Validation of ABI3 p.S209F Variant and Its effects On Early Brain Pathology in Asymptomatic Elderly Individuals

2025-10-13

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Alzheimer’s disease (AD) has a strong genetic component, with <italic>APOE</italic> ε4 being the most established risk factor through its effects on beta-amyloid (Aβ) metabolism and microglial function. Recent genetic studies have also implicated microglial genes, such as the ABI3 S209F variant, to increased AD risk. As <italic>APOE</italic>...

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Literature Corpus work: 17ec879c-ba26-5559-98b1-d5bbd5a2d6ec
DOI: 10.21203/rs.3.rs-7823342/v1

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