Article

Investigation of the ABI3 protein in microglia and its association with Alzheimer's disease in TgCRND8 mouse model

2021-01-01

Abstract excerpt

Recent genome wide-association studies (GWAS) have identified several disease-related genetic variants among Alzheimer's disease (AD) patients. A cluster of these genes, including TREM2, PLCG2 and ABI3, are highly expressed in microglia and their exact function in these cells is poorly understood. Since microglial dysfunction is thought to play an important role in AD pathogenesis, this thesis was aimed at analysi...

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Literature Corpus work: 2a174bf1-1ed1-5df5-acfe-867ceff28660
DOI: 10.17863/cam.75928

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