Article

Genetic Validation of ABI3 p.Ser209Phe Variant and Its effects On Early Brain Pathology in Asymptomatic Elderly Individuals

2025-12-22

Abstract excerpt

<title>Abstract</title> Background Alzheimer’s disease (AD) has a strong genetic component, with <italic>APOE</italic> ε4 being the most established risk factor through its effects on beta-amyloid (Aβ) metabolism and microglial function. Recent genetic studies have also implicated microglial genes, such as the ABI3 S209F variant, to increased AD risk. As <italic>APOE</italic> ε4 and ABI3 <...

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Literature Corpus work: fb3b9ea7-c755-596f-801b-27b309734553
DOI: 10.21203/rs.3.rs-8113148/v1

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