Article

Microglial BIN1 deficiency elicits enhanced microglial inflammatory responses that mimic early AD pathology

2025-08-14

Abstract excerpt

<title>Abstract</title> <p> Bridging Integrator 1 ( <italic>Bin1</italic> ) has been identified as the second most important risk locus for developing late-onset Alzheimer’s Disease (AD), after <italic>Apoe</italic> . BIN1 is an adaptor protein implicated in cell membrane dynamics and neuronal BIN1 has been linked to tau pathology and cellular transport mechanisms’ defects; however, the contribution of micro...

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Literature Corpus work: 22686049-acf8-5ee8-8a03-ceb75dea54e8
DOI: 10.21203/rs.3.rs-7262443/v1

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