Article

The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer’s disease progression

2024-10-03

Abstract excerpt

Microglia respond to Alzheimer’s disease (AD) with a variety of transcriptional responses. However, the regulation of specific transcriptional signatures and the contribution of each individual response to disease progression is only starting to be characterized. We have previously shown that hypoxia via hypoxia inducible factor 1 (HIF1) is a strong regulator of Aß plaque-associated microglia (AßAM). Here, we cha...

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Literature Corpus work: 5b16e8b1-9ffb-5e42-abd7-bce5b6617b00
DOI: 10.1101/2024.10.01.616066

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