Article

ABI3 deletion in TgCRND8 mice is associated with reduced amyloid plaque pathology and altered glial response

2023-10-07

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified several rare coding variants in a cluster of immune-related genes that are significantly associated with Alzheimer’s disease. This includes the risk variant (S209F) in ABI3 , a gene encoding the Abl Interactor family member 3 protein that is highly expressed in microglia, but little is known about its function in these cells and its association with AD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4c0fefe-3cb4-5c28-92f6-ca04e4f32f0e
DOI: 10.1101/2023.10.05.560956

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ABI3 deletion in TgCRND8 mice is associated with reduced amyloid plaque pathology and altered glial responseDOI 10.1101/2023.10.05.560956Read

Investigation of the ABI3 protein in microglia and its association with Alzheimer's disease in TgCRND8 mouse modelSemantic proximity Read

Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosisSemantic proximity Read

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity Read

Deletion of <i>Abi3</i> / <i>Gngt2</i> influences age-progressive amyloid β and tau pathologies in distinctive waysSemantic proximity Read

Abi3 regulates microglial ramification and dynamic tissue surveillance <i>in vivo</i>Semantic proximity Read

Immune receptor LAG3 regulates microglia function during Alzheimer’s diseaseSemantic proximity Read

Genetics ignite focus on microglial inflammation in Alzheimer's disease.Semantic proximity Read

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.Semantic proximity Read

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic miceSemantic proximity Read

Phospholipase D3 contributes to Alzheimer’s disease risk via disruption of Aβ clearance and microglia response to amyloid plaquesSemantic proximity Read

Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapySemantic proximity Read

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse modelSemantic proximity Read