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Article

Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases.

Immunity - 16 Jun 2020

Ohkura Naganari, Yasumizu Yoshiaki, Kitagawa Yohko, Tanaka Atsushi, Nakamura Yamami, Motooka Daisuke, Nakamura Shota, Okada Yukinori, Sakaguchi Shimon

Abstract excerpt

The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to common polygenic autoimmune diseases remains ambiguous. Here, we characterized genome-wide epigenetic profiles (CpG methylation and histone modifications) of human Treg and conventional T (Tconv) cells in naive and activated states. We found that single-nucleotide polymorphisms (SNPs) associated with common autoimmune diseases...

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Identifiers

PMID: 32362325
DOI: 10.1016/j.immuni.2020.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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