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Ferritin heavy chain supports stability and function of the regulatory T cell lineage

18 Mar 2024

Abstract excerpt

Regulatory T (TREG) cells develop via a program orchestrated by the transcription factor forkhead box protein P3 (FOXP3). Maintenance of the TREG cell lineage relies on sustained FOXP3 transcription via a mechanism involving demethylation of cytosine-phosphate-guanine (CpG)-rich elements at conserved non-coding sequences (CNS) in the FOXP3 locus. This cytosine demethylation is catalyzed by the ten-eleven...

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PMID: 38499786
DOI: 10.1038/s44318-024-00064-x

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