Article

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

2023-04-21

Abstract excerpt

During the progression of pancreatic ductal adenocarcinoma (PDAC), tumor cells are known to acquire transcriptional and morphological properties of the basal (also known as squamous) epithelial lineage, which leads to more aggressive disease characteristics. Here, we show that a subset of basal-like PDAC tumors aberrantly express p73 (TA isoform), which is a known transcriptional activator of basal lineage identit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d339770c-7d8f-5da6-a5ea-5de43025caa8
DOI: 10.1101/2023.04.20.537667

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinomaDOI 10.1101/2023.04.20.537667Read

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationSemantic proximity Read

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal AdenocarcinomaSemantic proximity Read

p53 and YAP/TAZ-TEAD activities determine metaplastic heterogeneity in pancreatic cancerSemantic proximity Read

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinomaSemantic proximity Read

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinomaSemantic proximity Read

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancerSemantic proximity Read

Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic CancerSemantic proximity Read

Multifaceted role for p53 in pancreatic cancer suppressionSemantic proximity Read

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injurySemantic proximity Read

Cell of Origin Influences Pancreatic Cancer Subtype.Semantic proximity Read

The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic CapacitySemantic proximity Read

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinomaSemantic proximity Read