Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

1 Nov 2018

Abstract excerpt

The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the functional role of this putative transdifferentiation event in PDA pathogenesis remains unclear. Here, we show that expression of the transcription factor TP63 (ΔNp63) is sufficient to install and sustain the enhancer landscape and transcriptional signature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30428345
DOI: 10.1016/j.celrep.2018.10.051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal AdenocarcinomaPMID 30428345Read ↗

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor networkSemantic proximity Read ↗

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammationSemantic proximity Read ↗

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationSemantic proximity Read ↗

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancySemantic proximity Read ↗

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

SPDEF promotes the classical subtype of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate ConversionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.