Article

The Loss of the E3 ubiquitin ligase TRIP12 inhibits Pancreatic Acinar Cell Plasticity and Tumor Cell Metastatic Capacity

2023-03-10

Abstract excerpt

<h4>Background & Aims</h4> Although specialized and dedicated to the production of digestive enzymes, pancreatic acinar cells harbor a high plasticity and are able to modify their identity. They undergo reversible acinar-to-ductal cell metaplasia (ADM) through epigenetic silencing of the acinar lineage gene program mainly controlled by PTF1a (Pancreas Transcription Factor 1a). ADM becomes irreversible in the pres...

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Literature Corpus work: 2214605f-4861-5162-baf9-b48578b5128b
DOI: 10.1101/2023.03.08.531649

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