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Article

p53 and YAP/TAZ-TEAD activities determine metaplastic heterogeneity in pancreatic cancer

2025-12-15

Abstract excerpt

<h4>BACKGROUND and AIMS</h4> Pancreatic ductal adenocarcinoma (PDAC) initiation and progression is characterized by lineage plasticity across a continuum of metaplastic and malignant cell fates. This molecular heterogeneity influences disease progression and therapeutic response, yet the genetic and molecular interactions underlying cellular plasticity during PDAC progression remain poorly understood. Here we stu...

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Literature Corpus work
0f6532ae-b886-5252-a5e3-fd026e1034c2
DOI
10.64898/2025.12.11.693520
Open publication

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