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Article

Multifaceted role for p53 in pancreatic cancer suppression

27 Feb 2023

Abstract excerpt

The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53’s critical role in PDAC suppression. PDAC can arise when pancreatic acinar cells undergo acinar-to-ductal metaplasia (ADM), giving rise to premalignant pancreatic intraepithelial neoplasias (PanINs), which finally progress to PDAC. The occurrence of TP53 mutations in late-stage PanINs has led to the idea...

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PMID: 36848578
DOI: 10.1073/pnas.2211937120

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