Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell of Origin Influences Pancreatic Cancer Subtype.

Cancer discovery - 1 Mar 2021

Flowers Brittany M, Xu Hang, Mulligan Abigail S, Hanson Kathryn J, Seoane Jose A, Vogel Hannes, Curtis Christina, Wood Laura D, Attardi Laura D

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 9%. An improved understanding of PDAC initiation and progression is paramount for discovering strategies to better detect and combat this disease. Although transcriptomic analyses have uncovered distinct molecular subtypes of human PDAC, the factors that influence subtype development remain unclear. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acinar Cells
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Disease Susceptibility

Share to Kaplan-Meier Estimate

Share to Oncogenes

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 34009137
DOI: 10.1158/2159-8290.CD-20-0633
PMCID: PMC8134763

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell of Origin Influences Pancreatic Cancer Subtype.PMID 34009137Read ↗

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem CellsSemantic proximity Read ↗

Molecular Pathogenesis of Pancreatic Cancer: Advances and ChallengesSemantic proximity Read ↗

Ecoevolutionary biology of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.Semantic proximity Read ↗

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular OriginSemantic proximity Read ↗

Pancreatic CancerSemantic proximity Read ↗

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data.Semantic proximity Read ↗

Pancreatic cancer biology and genetics.Semantic proximity Read ↗

Ductal vs. acinar? Recent insights into identifying cell lineage of pancreatic ductal adenocarcinomaSemantic proximity Read ↗

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationSemantic proximity Read ↗

The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.