Article

Essential gene networks in acute myeloid leukemia identified using a <i>microRNA</i> -knockout CRISPR library screen

2019-06-06

Abstract excerpt

MicroRNAs (miRNA) are small RNAs that function as key modulators of gene expression. Due to their promiscuity of binding, a single miRNA may regulate several genes and hence, multiple pathways simultaneously. In addition, the 3’-UTR of mRNA can be recognized by several miRNA for suppression or degradation. We built a mi cro R NA-only K nock- o ut (miRKo) CRISPR/Cas-9 library to identify essential miRNA in Acut...

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Literature Corpus work: d316b6dc-f235-5c10-bc5e-3beb9b1aa584
DOI: 10.1101/661140

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