Article

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

2024-07-16

Abstract excerpt

RNA modification pathways are mis-regulated in multiple types of human cancer. To comprehensively identify cancer-relevant RNA modifications and their regulators, we screened all 150 annotated human RNA modifying proteins across 18 different normal and cancer cell lines using a CRISPR-based genetic knockout system. Fifty RNA modifying proteins were essential for survival of at least one cell type. A third of these...

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Literature Corpus work: a6952f69-e026-58a6-ad1d-6cd4a39335df
DOI: 10.1101/2024.07.13.603368

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