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Functional Dependency Analysis Identifies Potential Druggable Targets in Acute Myeloid Leukemia

10 Dec 2020

Abstract excerpt

Refractory disease is a major challenge in treating patients with acute myeloid leukemia (AML). Whereas the armamentarium has expanded in the past few years for treating AML, long-term survival outcomes have yet to be proven. To further expand the arsenal for treating AML, we searched for druggable gene targets in AML by analyzing screening data from a lentiviral-based genome-wide pooled CRISPR-Cas9 library and...

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PMID: 33321907
DOI: 10.3390/cancers12123710

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